Tracing the source of campylobacteriosis

Finally, it's out! The main piece of work to come out of my two-year period as Research Associate at Lancaster University is published today in PLoS Genetics.

The article reports a study in Lancashire, England, of the bacterium Campylobacter jejuni, the primary cause of bacterial gastro-enteritis in developed countries. We inferred the source of infection in 1,200 patients by comparing the DNA sequences of C. jejuni taken from those patients to 1,100 taken from different animal species and the environment. The result: livestock are the source of infection in 97% of cases.

In addition to preparing the figures, approving final drafts, and producing a press release in conjunction with the PLoS Genetics and university press offices, I have spent much of my time over the last three weeks revising a companion paper on the evolution of C. jejuni. On Friday that was resubmitted to Molecular Biology and Evolution, and should it be accepted, will draw a line under my Lancaster projects.

What do researchers do?

Most of my friends (and maybe even my colleagues) don't have much idea of what I do day-to-day. That's the subject of this blog. Modern research is quantified in terms of published articles, but that forms just a small part of daily working life, and the process from conceiving an interesting question or idea to published article is a long and tortuous one. Often articles aren't published until months or years after the research was conducted, and so there is a time-lag between what appears in print and what the current focus of research is. By that time the initial excitement of pursuing novel work is a distant memory, having been supplanted by several rounds of peer review, revision and resubmission.

So this is an attempt to communicate what I am doing now, to talk about what I think's exciting this week (or this afternoon) and to show what being a researcher means on a daily basis.